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A brain serine/threonine protein kinase activated by Cdc42 and Rac1.

Affiliations

1. Institute of Molecular & Cell Biology, National University of Singapore, Kent Ridge.
Authors
Manser E¹
(1 author)

Nature, 01 Jan 1994, 367(6458):40-46
https://doi.org/10.1038/367040a0 PMID: 8107774

Abstract

A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.

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Read article at publisher's site: https://doi.org/10.1038/367040a0

References

Articles referenced by this article (49)

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Other citations

Wikipedia

https://en.wikipedia.org/wiki/PAK1

Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

Diseases in OMIM (4)

RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1; RAC1(OMIM - 602048)
p21 PROTEIN-ACTIVATED KINASE 1; PAK1(OMIM - 602590)
p21 PROTEIN-ACTIVATED KINASE 3; PAK3(OMIM - 300142)
CELL DIVISION CYCLE 42; CDC42(OMIM - 116952)

Gene Ontology Annotation Project

https://www.ebi.ac.uk/QuickGO/annotations?reference=8107774

Proteins in UniProt (Showing 5 of 84)

Pleckstrin homology domain-containing family G member 3(UniProt - A1L390)
WAS/WASL-interacting protein family member 3(UniProt - A6NGB9)
Phospholipase D2(UniProt - O14939)
Serine/threonine-protein kinase PAK 3(UniProt - O75914)
Synaptosomal-associated protein 23(UniProt - O00161)

Go to all (84) records in UniProt

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/8107774

Nucleotide sequences in ENA (Showing 5 of 6)

Rattus norvegicus serine/threonine kinase (gamma-PAK) mRNA, complete cds.(ENA - U35345)
Rattus norvegicus serine/threonine protein kinase (alpha-PAK) mRNA,complete cds.(ENA - U23443)
Rattus norvegicus (Norway rat) serine/threonine protein kinase(ENA - AAB95646)
Rattus norvegicus (Norway rat) beta-PAK(ENA - AAC52268)
Rattus norvegicus serine/threonine kinase beta-PAK mRNA, complete cds.(ENA - U33314)

Go to all (6) records in ENA

Protein families in InterPro (2)

CRIB_dom(InterPro - IPR000095)
CRIB_dom_sf(InterPro - IPR036936)

Protein interactions in IntAct (2)

rac1-pak1-10(IntAct - EBI-8639634)
pak1-cdc42-11(IntAct - EBI-8639606)

The Rat Genome Database (RGD) was established in 1999 and rapidly became the premier site for genetic, genomic, phenotype, and disease-related data generated from rat research. In addition, RGD has expanded to include a large body of structured and standardized data for eight species (rat, mouse, human, chinchilla, bonobo, 13-lined ground squirrel, dog and pig). Much of this data is the result of manual curation work by RGD curators. In other instances, it has been imported into RGD from other databases through custom ELT (Extract, Load and Transform) pipelines giving RGD users integrated access to a wide variety of data to support their research efforts. RGD also offers a growing suite of innovative tools for querying, analyzing and visualizing this data making it a valuable resource for researchers worldwide. (Showing 10 of 50)

Reactome (2)

SIGNOR

https://signor.uniroma2.it/pmidSearch.php?pmid=8107774

Saccharomyces Genome Database

https://www.yeastgenome.org/reference/S000077769

WikiPathways

https://www.wikipathways.org/instance/WP376

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