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Adhesion forces between individual ligand-receptor pairs.

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Affiliations

  • 1. Physikdepartment der Technischen Universität München, Garching, Germany.
      Authors
    • Florin EL 1
    (1 author)

Science, 01 Apr 1994, 264(5157):415-417
https://doi.org/10.1126/science.8153628 PMID: 8153628 

Abstract 

The adhesion force between the tip of an atomic force microscope cantilever derivatized with avidin and agarose beads functionalized with biotin, desthiobiotin, or iminobiotin was measured. Under conditions that allowed only a limited number of molecular pairs to interact, the force required to separate tip and bead was found to be quantized in integer multiples of 160 +/- 20 piconewtons for biotin and 85 +/- 15 piconewtons for iminobiotin. The measured force quanta are interpreted as the unbinding forces of individual molecular pairs.

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Read article at publisher's site: https://doi.org/10.1126/science.8153628

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