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The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.

Affiliations

1. Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
Authors
Papa FR¹
(1 author)

ORCIDs linked to this article

Nature, 01 Nov 1993, 366(6453):313-319
https://doi.org/10.1038/366313a0 PMID: 8247125

Abstract

Modification of specific intracellular proteins by ubiquitin targets them for degradation. We describe a yeast enzyme, Doa4, that is integral to the degradation of ubiquitinated proteins and is required in diverse physiological processes. Doa4 appears to function late in the proteolytic pathway by cleaving ubiquitin from substrate remnants still bound to protease. The human tre-2 oncogene encodes a deubiquitinating enzyme similar to Doa4, indicating a role for the ubiquitin system in mammalian growth control.

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Read article at publisher's site: https://doi.org/10.1038/366313a0

References

Articles referenced by this article (46)

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Wikipedia

https://en.wikipedia.org/wiki/USP6

Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

Gene Ontology Annotation Project

https://www.ebi.ac.uk/QuickGO/annotations?reference=8247125

Proteins in UniProt (2)

Ubiquitin carboxyl-terminal hydrolase 4(UniProt - P32571)
Ubiquitin carboxyl-terminal hydrolase 6(UniProt - P35125)

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/8247125

Nucleotide sequences in ENA (2)

Saccharomyces cerevisiae (baker's yeast) deubiquitinating enzyme(ENA - AAC48915)
Saccharomyces cerevisiae deubiquitinating enzyme (DOA4) gene, complete cds.(ENA - U02518)

Saccharomyces Genome Database

https://www.yeastgenome.org/reference/S000045956

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