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Interaction of activated EGF receptors with coated pit adaptins.

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Affiliations

  • 1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146.
      Authors
    • Sorkin A 1
    (1 author)

ORCIDs linked to this article

Science, 01 Jul 1993, 261(5121):612-615
https://doi.org/10.1126/science.8342026 PMID: 8342026 

Abstract 

The epidermal growth factor (EGF) receptor interacts with plasma membrane-associated adapter proteins during endocytosis through coated pits. Almost 50 percent of the total pool of alpha-adaptins was coimmunoprecipitated with the EGF receptor when A-431 cells were treated with EGF at 37 degrees C, but not at 4 degrees C. Partial proteolysis of alpha-adaptin suggested that the amino-terminal domain is the region that associates with the EGF receptor. The extent of receptor-adaptin association was increased in cells depleted of potassium to block endocytosis. These data suggest that receptor-adaptin association occurs in intact cells before coated pits are fully assembled.

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Funding 

Funders who supported this work.

NCI NIH HHS (1)