Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Cell death by apoptosis in epidermal biology.

Author information

Affiliations

  • 1. Department of Dermatology, University of Rochester, New York 14642.
      Authors
    • Haake AR 1
    (1 author)

The Journal of Investigative Dermatology, 01 Aug 1993, 101(2):107-112
https://doi.org/10.1111/1523-1747.ep12363594 PMID: 8345210 

Review

Abstract 

Homeostasis in continually renewing tissues is maintained by a tightly regulated balance between cell proliferation, cell differentiation, and cell death. Until recently, proliferation was thought to be the primary point of control in the regulation of normal tissue kinetic homeostasis and as such has been the major focus of both understanding the etiology of disease and developing therapeutic strategies. Now, physiologic cell death, known as apoptosis (ă-pŏp-to' sĭs, ă-po-to' sĭs [Thomas CL (ed.): Taber's Cyclopedic Medical Dictionary. F.A. Davis, Co., Philadelphia, 1989)] has gained scientific recognition as an active regulatory mechanism, complementary, but functionally opposite, to proliferation with important roles in shaping and maintaining tissue size and prevention of disease. In this review we will describe the concept of apoptosis and discuss possible molecular mechanisms of its regulation that may have implications for skin biology.

Full text links 

Read article at publisher's site: https://doi.org/10.1111/1523-1747.ep12363594

References 

Articles referenced by this article (59)

Show 10 more references (10 of 59)

Citations & impact 

Impact metrics

164
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (164) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NIAMS NIH HHS (1)

NICHD NIH HHS (1)