T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.

Itohara S; Mombaerts P; Lafaille J; Iacomini J; Nelson A; Clarke AR; Hooper ML; Farr A; Tonegawa S

doi:10.1016/0092-8674(93)90112-4

T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.

Farr A ,

Affiliations

1. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.
Authors
Itohara S¹
(1 author)

ORCIDs linked to this article

Cell, 01 Feb 1993, 72(3):337-348
https://doi.org/10.1016/0092-8674(93)90112-4 PMID: 8381716

Abstract

T cells bearing T cell receptor (TCR) gamma and delta chain heterodimers are first generated early in ontogeny. They form distinct subsets that differ in their TCR repertoires and tissue distribution. Disruption of the mouse TCR C delta gene segment by a gene targeting method caused the complete loss of T cells bearing TCR gamma delta chains, but had little or no effect on the development of T cells bearing TCR alpha beta chains. The analyses of TCR gamma and delta genes in the mutant mice suggest that intracellular mechanisms acting at the level of DNA rearrangement play key roles in the differential gamma and delta gene rearrangements and in the generation of the highly restricted junctional sequences during fetal thymic development.

Full text links

Read article at publisher's site: https://doi.org/10.1016/0092-8674(93)90112-4

References

Articles referenced by this article (51)

The immunobiology of T cells with invariant gamma delta antigen receptors.
Allison JP, Havran WL
Annu Rev Immunol, 679-705 1991
MED: 1832874
Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells.
Asarnow DM, Kuziel WA, Bonyhadi M, Tigelaar RE, Tucker PW, Allison JP
Cell, (5):837-847 1988
MED: 2847872
The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3.
Avner PR, Dove WF, Dubois P, Gaillard JA, Guenet JL, Jacob F, Jakob H, Shedlovsky A
Immunogenetics, (1):103-115 1978
MED: 21302063
Blockage of alpha beta T-cell development by TCR gamma delta transgenes.
Bonneville M, Ishida I, Mombaerts P, Katsuki M, Verbeek S, Berns A, Tonegawa S
Nature, (6252):931-934 1989
MED: 2480528
Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity.
Bonneville M, Itohara S, Krecko EG, Mombaerts P, Ishida I, Katsuki M, Berns A, Farr AG, Janeway CA Jr, Tonegawa S
J Exp Med, (4):1015-1026 1990
MED: 2109035
Simultaneous immunoenzyme double labelling using two different enzymes linked directly to monoclonal antibodies or with biotin-avidin.
Boorsma DM, VanBommel J, VanderRaaij-Helmer EM
J Microsc, (Pt 2):197-203 1986
MED: 3531527
Production and analysis of chimeric mice
Bradley
1987
Altering the genome by homologous recombination.
Capecchi MR
Science, (4910):1288-1292 1989
MED: 2660260
T-cell receptor delta gene rearrangements in early thymocytes.
Chien YH, Iwashima M, Wettstein DA, Kaplan KB, Elliott JF, Born W, Davis MM
Nature, (6150):722-727 1987
MED: 2961997
The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.
Elliott JF, Rock EP, Patten PA, Davis MM, Chien YH
Nature, (6157):627-631 1988
MED: 2963227

Show 10 more references (10 of 51)

Citations & impact

Impact metrics

346

Citations

Jump to Citations

Data citation

Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/35496133

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/35496133

Article citations

γδ T Cells Mediate a Requisite Portion of a Wound Healing Response Triggered by Cutaneous Poxvirus Infection.
Reider IE, Lin E, Krouse TE, Parekh NJ, Nelson AM, Norbury CC
Viruses, 16(3):425, 10 Mar 2024
Cited by: 0 articles | PMID: 38543790 | PMCID: PMC10975054
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
TCR signaling and cellular metabolism regulate the capacity of murine epidermal γδ T cells to rapidly produce IL-13 but not IFN-γ.
Ibusuki A, Kawai K, Nitahara-Takeuchi A, Argüello RJ, Kanekura T
Front Immunol, 15:1361139, 28 Feb 2024
Cited by: 0 articles | PMID: 38482017 | PMCID: PMC10933099
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
An axon-T cell feedback loop enhances inflammation and axon degeneration.
Liu T, Wang H, Kutsovsky DY, Iskols M, Chen H, Ohn CYJ, Patel N, Yang J, Simon DJ
Cell Rep, 43(2):113721, 03 Feb 2024
Cited by: 0 articles | PMID: 38310514 | PMCID: PMC11463236
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis.
Wang S, Kozai M, Hiraishi M, Rubel MZU, Ichii O, Inaba M, Matsuo K, Takada K
Front Immunol, 15:1340467, 29 Jan 2024
Cited by: 0 articles | PMID: 38348035 | PMCID: PMC10859483
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.
Ruchti F, Tuor M, Mathew L, McCarthy NE, LeibundGut-Landmann S
PLoS Pathog, 20(1):e1011668, 12 Jan 2024
Cited by: 1 article | PMID: 38215167 | PMCID: PMC10810444
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC

Go to all (346) article citations

Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

Mouse Genome Informatics (MGI)

http://www.informatics.jax.org/reference/8381716

Search life-sciences literature (45,103,589 articles, preprints and more)

T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

The immunobiology of T cells with invariant gamma delta antigen receptors.

Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells.

The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3.

Blockage of alpha beta T-cell development by TCR gamma delta transgenes.

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity.

Simultaneous immunoenzyme double labelling using two different enzymes linked directly to monoclonal antibodies or with biotin-avidin.

Production and analysis of chimeric mice

Altering the genome by homologous recombination.

T-cell receptor delta gene rearrangements in early thymocytes.

The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

γδ T Cells Mediate a Requisite Portion of a Wound Healing Response Triggered by Cutaneous Poxvirus Infection.

TCR signaling and cellular metabolism regulate the capacity of murine epidermal γδ T cells to rapidly produce IL-13 but not IFN-γ.

An axon-T cell feedback loop enhances inflammation and axon degeneration.

Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis.

γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control.

Data

Data that cites the article

Mouse Genome Informatics (MGI)

Similar Articles

A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors.

Junctional diversity in the absence of N regions. Neonatal T cell receptor beta chain junctional sequences are more heterogeneous than neonatal T cell receptor gamma delta or IgH junctions.

Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.

Gamma delta T-cell development.

Partnerships & funding

Similar Articles

A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors.
Eur J Immunol, 28(3):828-837, 01 Mar 1998

Junctional diversity in the absence of N regions. Neonatal T cell receptor beta chain junctional sequences are more heterogeneous than neonatal T cell receptor gamma delta or IgH junctions.
J Immunol, 151(6):3094-3099, 01 Sep 1993

Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.

Gamma delta T-cell development.
Curr Opin Immunol, 5(2):241-246, 01 Apr 1993

Search life-sciences literature (45,103,589 articles, preprints and more)

T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.

Author information

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Production and analysis of chimeric mice

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Data

Data that cites the article

Mouse Genome Informatics (MGI)

Similar Articles

Partnerships & funding