Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis.

Author information

Affiliations

  • 1. Institute of Human Anatomy, University of Ferrara, Italy.
      Authors
    • Zauli G 1
    (1 author)

Cancer Research, 01 Oct 1993, 53(19):4481-4485
PMID: 8402618 

Abstract 

We report here that the tat gene product of human immunodeficiency virus type 1 was able to protect lymphoblastoid (Jurkat), epithelial (293) and neuronal (PC12) cell lines from apoptotic death induced by serum withdrawal. The rescue from apoptosis by Tat was reflected by an increased expression of Bcl-2 protein in tat-positive Jurkat cells with respect to mock-transfected Jurkat cells after 3-6 days of serum-free cultures. We propose that the ability of the regulatory human immunodeficiency virus type 1 Tat protein to suppress apoptosis might have important implications in understanding the pathogenesis of frequent neoplastic disorders observed in human immunodeficiency virus type 1-seropositive individuals.

Full text links 

Free to read at cancerres.aacrjournals.org
http://cancerres.aacrjournals.org/cgi/content/abstract/53/19/4481

Citations & impact 

Impact metrics

80
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (80) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.