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Conditioned narcotic withdrawal in humans.

Science, 01 Mar 1977, 195(4282):1000-1002
https://doi.org/10.1126/science.841320 PMID: 841320 

Abstract 

Subjective and physiological manifestations of the narcotic withdrawal syndrome were produced as a conditioned response. Withdrawal reactions precipitated by the narcotic antagonist naloxone in methadone-dependent volunteers were the unconditioned response. These data support clinical anecdotes of withdrawal symptoms occurring in former addicts when they return to their drug-related environment.

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Read article at publisher's site: https://doi.org/10.1126/science.841320

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