Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Origin of human trisomics and polyploids.

Human Heredity, 01 Jan 1977, 27(1):59-72
https://doi.org/10.1159/000152852 PMID: 844886 

Abstract 

A mathematical theory is derived for the distribution of heteromorphisms in trisomics and polyploids. Applied to the sparse literature, it appears that most trisomy 21 is due to first division maternal nondisjunction, although there are case reports of second division nondisjunction, both paternal and maternal. Most triploids appear to be due to dispermy or failure of the first meiotic division in the oocyte. The need for larger systematic samples is stressed. This maximum likelihood analysis gives great resolution to epidemiological studies, permitting discrimination of etiological factors acting on fathers and mothers, at different meiotic stages, and on dispermy.

Full text links 

Read article at publisher's site: https://doi.org/10.1159/000152852

Citations & impact 

Impact metrics

45
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (45) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.