Signal transduction. How receptors turn Ras on.

McCormick F

doi:10.1038/363015a0

Signal transduction. How receptors turn Ras on.

Nature, 01 May 1993, 363(6424):15-16
https://doi.org/10.1038/363015a0 PMID: 8479530

This is a comment on "Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras." Nature. 1993 May 6;363(6424):88-92. This is a comment on "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation." Nature. 1993 May 6;363(6424):45-51. This is a comment on "The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1." Nature. 1993 May 6;363(6424):83-5. Show all (4)

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References

Articles referenced by this article (14)

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.
Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA
Nature, (6424):45-51 1993
MED: 8479536
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J
Nature, (6424):85-88 1993
MED: 8479541
Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.
Gale NW, Kaplan S, Lowenstein EJ, Schlessinger J, Bar-Sagi D
Nature, (6424):88-92 1993
MED: 8386805
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D
Nature, (6424):83-85 1993
MED: 8479540
An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.
Simon MA, Dodson GS, Rubin GM
Cell, (1):169-177 1993
MED: 8462097
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T
Cell, (1):179-191 1993
MED: 8462098
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.
Buday L, Downward J
Cell, (3):611-620 1993
MED: 8490966
Chardin, P. et al. Science (in the press).
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.
Koch CA, Anderson D, Moran MF, Ellis C, Pawson T
Science, (5006):668-674 1991
MED: 1708916
Signalling through SH2 and SH3 domains.
Mayer BJ, Baltimore D
Trends Cell Biol, (1):8-13 1993
MED: 14731533

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Protein son of sevenless(UniProt - P26675)
Growth factor receptor-bound protein 2(UniProt - Q08012)

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Signal transduction. How receptors turn Ras on.

Abstract

Full text links

References

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras.

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.

An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.

Chardin, P. et al. Science (in the press).

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins.

Signalling through SH2 and SH3 domains.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.

Female tilapia, Oreochromis sp. mobilised energy differently for growth and reproduction according to living environment.

40 Years of RAS-A Historic Overview.

Drug resistance in targeted cancer therapies with RAF inhibitors.

Insulin signaling in health and disease.

Data

Data that cites the article

FlyBase

Proteins in UniProt (2)

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.
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