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Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing.

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Affiliations

  • 1. Differentiation Program, European Molecular Biology Laboratory, Heidelberg, Germany.
      Authors
    • Diaz-Benjumea FJ 1
    (1 author)

Development (Cambridge, England), 01 Dec 1995, 121(12):4215-4225
https://doi.org/10.1242/dev.121.12.4215 PMID: 8575321 

Abstract 

Growth and patterning of the Drosophila wing is controlled by organizing centers located at the anterior-posterior and dorsal-ventral compartment boundaries. Interaction between cells in adjacent compartments establish the organizer. We report here that Serrate and Notch mediate the interaction between dorsal and ventral cells to direct localized expression of Wingless at the D/V boundary. Serrate serves as a spatially localized ligand which directs Wg expression through activation of Notch. Ligand independent activation of Notch is sufficient to direct Wg expression, which in turn mediates the organizing activity of the D/V boundary.

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Read article at publisher's site: https://doi.org/10.1242/dev.121.12.4215

Free to read at dev.biologists.org
http://dev.biologists.org/cgi/content/abstract/121/12/4215

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