Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Effects of beta cell granule components on human islet amyloid polypeptide fibril formation.

Author information

Affiliations

  • 1. Department of Pathology, Linköping University, Sweden.
      Authors
    • Westermark P 1
    (1 author)

FEBS Letters, 01 Feb 1996, 379(3):203-206
https://doi.org/10.1016/0014-5793(95)01512-4 PMID: 8603689 

Abstract 

Formation of amyloid-like fibrils in a solution of human islet amyloid polypeptide (hIAPP) with and without the presence of other beta-cell granule components was studied in vitro. Insulin at less than equimolar concentration strongly inhibited hIAPP fibrillogenesis. Proinsulin had a weaker inhibitory effect while C-peptide, Ca2+ and Zn2+ each individually enhanced fibril formation. C-peptide combined with Ca2+ had an inhibitory effect. Since IAPP was found almost exclusively in the halo fractions of isolated islet secretory granules, primarily the concentrations of C-peptide, Ca2+ and possibly proinsulin may be crucial for the native state of IAPP. It is concluded that an imbalance between fibril formation enhancers and inhibitors may be of importance in the pathogenesis of amyloid in the islets of Langerhans.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/0014-5793(95)01512-4

Read article for free, from open access legal sources, via Unpaywall: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2895%2901512-4Unpaywall

References 

Articles referenced by this article (20)

Show 10 more references (10 of 20)

Citations & impact 

Impact metrics

130
Citations
Jump to Citations

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/0014-5793(95)01512-4

Supporting
Mentioning
Contrasting
8
200
3

Article citations

Go to all (130) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NIDDK NIH HHS (1)