1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.

Jain RK

doi:10.1007/bf02648108

Abstract

To reach cancer cells in a tumor, a blood-borne therapeutic agent must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then to integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.

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References

Articles referenced by this article (132)

Arbit, E., J. Lee, and G. DiResta. Interstitial hypertension in human brain tumors: possible role in peritumoral edema formation. In: Intracranial Pressure, edited by H. Nagai, K. Kamiya, and S. Ishii. Tokyo: Springer-Verlag, 1994, pp. 609–614.
Baish, J. W., Y. Gazit, D. A. Berk, M. Nozue, L. T. Baxter, and R. K. Jain. Role of tumor vascular architecture in nutrient and drug delivery: An invasion percolation based network model.Microvasc. Res., in press.
Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.
Baxter LT, Jain RK
Br J Cancer, (4):447-456 1996
MED: 8595158
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Baxter LT, Jain RK
Microvasc Res, (1):77-104 1989
MED: 2646512
Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.
Baxter LT, Jain RK
Microvasc Res, (2):246-263 1990
MED: 2250603
Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.
Baxter LT, Jain RK
Microvasc Res, (1):5-23 1991
MED: 2051954
Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.
Baxter LT, Jain RK
Microvasc Res, (2):252-272 1991
MED: 2051960
Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.
Baxter LT, Yuan F, Jain RK
Cancer Res, (20):5838-5844 1992
MED: 1394212
Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.
Baxter LT, Zhu H, Mackensen DG, Butler WF, Jain RK
Cancer Res, (20):4611-4622 1995
MED: 7553638
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.
Baxter LT, Zhu H, Mackensen DG, Jain RK
Cancer Res, (6):1517-1528 1994
MED: 8137258

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Search life-sciences literature (45,103,589 articles, preprints and more)

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.

Affiliations

Authors

Abstract

Full text links

References

Arbit, E., J. Lee, and G. DiResta. Interstitial hypertension in human brain tumors: possible role in peritumoral edema formation. In: Intracranial Pressure, edited by H. Nagai, K. Kamiya, and S. Ishii. Tokyo: Springer-Verlag, 1994, pp. 609–614.

Baish, J. W., Y. Gazit, D. A. Berk, M. Nozue, L. T. Baxter, and R. K. Jain. Role of tumor vascular architecture in nutrient and drug delivery: An invasion percolation based network model.Microvasc. Res., in press.

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data.

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics.

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism.

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution.

Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data.

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/bf02648108

Article citations

Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas.

Early hypertension and neutropenia are predictors of treatment efficacy in metastatic colorectal cancer patients administered FOLFIRI and vascular endothelial growth factor inhibitors as second-line chemotherapy.

Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy.

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.

Angiogenic inhibitors in gastric cancers and gastroesophageal junction carcinomas: A critical insight.

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Search life-sciences literature (45,103,589 articles, preprints and more)

1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.

Author information

Affiliations

Authors

Abstract

Full text links

References

Arbit, E., J. Lee, and G. DiResta. Interstitial hypertension in human brain tumors: possible role in peritumoral edema formation. In: Intracranial Pressure, edited by H. Nagai, K. Kamiya, and S. Ishii. Tokyo: Springer-Verlag, 1994, pp. 609–614.

Baish, J. W., Y. Gazit, D. A. Berk, M. Nozue, L. T. Baxter, and R. K. Jain. Role of tumor vascular architecture in nutrient and drug delivery: An invasion percolation based network model.Microvasc. Res., in press.

Citations & impact

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Citations of article over time

Alternative metrics

Article citations

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