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Metastasis results from preexisting variant cells within a malignant tumor.

Science, 01 Aug 1977, 197(4306):893-895
https://doi.org/10.1126/science.887927 PMID: 887927 

Abstract 

Clones derived in vitro from a parent culture of murine malignant melanoma cells varied greatly in their ability to produce metastatic colonies in the lungs upon intravenous inoculation into syngeneic mice. This suggests that the parent tumor is heterogeneous and that highly metastatic tumor cell variants preexist in the parental population.

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Read article at publisher's site: https://doi.org/10.1126/science.887927

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