Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis.

Author information

Affiliations

  • 1. Department of Neurology, University of Turin, Italy.
      Authors
    • Schiffer D 1
    (1 author)

ORCIDs linked to this article

Journal of the Neurological Sciences, 01 Aug 1996, 139 Suppl:27-33
https://doi.org/10.1016/0022-510x(96)00073-1 PMID: 8899654 

Abstract 

Many observations have been carried out on astrogliosis in the cerebral cortex in amyotrophic lateral sclerosis (ALS), whereas little attention has been paid to astrogliosis in the spinal cord. Twenty autopsy cases of sporadic, common form of ALS have been studied. Spinal cords have been examined at the cervical, thoracic and lumbar levels by histological methods and immunohistochemistry for GFAP, Vimentin, Tau-protein, Neurofilaments, PCNA. A gliosis was found in the ventral horns, in dorsal horns and at the transition between gray matter and anterior and lateral funiculi, especially close to laminae VII, VI and V as being due to secondary gliosis. The findings cannot be interpreted on the only basis of the substitutive role of reacting glia. The proposed pathogenetic mechanisms of ALS are evaluated as possible responsible stimuli; the coincidence of the distribution of reactive astrocytes with the entering points of the corticospinal tracts into the gray matter is considered of primary importance. Of special interest are reactive astrocytes at the transition between laminae VII, VI and V and the lateral funiculus, where dystrophic neurites are known to concentrate.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/0022-510x(96)00073-1

References 

Articles referenced by this article (39)

Show 10 more references (10 of 39)

Citations & impact 

Impact metrics

156
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/42038507
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/42038507

Article citations

Go to all (156) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.