How receptors talk to trimeric G proteins.

Bourne HR

doi:10.1016/s0955-0674(97)80054-3

How receptors talk to trimeric G proteins.

Bourne HR ¹

Affiliations

1. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
Authors
Bourne HR¹
(1 author)

Current Opinion in Cell Biology, 01 Apr 1997, 9(2):134-142
https://doi.org/10.1016/s0955-0674(97)80054-3 PMID: 9069253

Review

Abstract

Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the alpha subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, the surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.

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References

Articles referenced by this article (66)

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Search life-sciences literature (45,103,589 articles, preprints and more)

How receptors talk to trimeric G proteins.

Affiliations

Authors

Abstract

Full text links

References

Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function.

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2.

The 2.0 A crystal structure of a heterotrimeric G protein.

Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.

Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.

Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells.

The family of G-protein-coupled receptors.

Sequence alignment of the G-protein coupled receptor superfamily.

Projection structure of rhodopsin.

Projection structure of frog rhodopsin in two crystal forms.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands.

Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies.

The mechanism for ligand activation of the GPCR-G protein complex.

Pharmacology of the Umami Taste Receptor.

The G protein-first activation mechanism of opioid receptors by Gi protein and agonists.

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How receptors talk to trimeric G proteins.

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