CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.

Mendiratta SK; Martin WD; Hong S; Boesteanu A; Joyce S; Van Kaer L

doi:10.1016/s1074-7613(00)80290-3

Abstract

Murine CD1 has been implicated in the development and function of an unusual subset of T cells, termed natural T (NT) cells, that coexpress the T cell receptor (TCR) and the natural killer cell receptor NK1.1. Activated NT cells promptly produce large amounts of IL-4, suggesting that these cells can influence the differentiation of CD4+ effector T cell subsets. We have generated mice that carry a mutant CD1d1 gene. NT cell numbers in the thymus, spleen, and liver of these mice were dramatically reduced. Activated splenocytes from mutant mice did not produce IL-4, whereas similarly treated wild-type splenocytes secreted large amounts of this cytokine. These results demonstrate a critical role for CD1 in the positive selection and function of NT cells.

Full text links

Read article at publisher's site: https://doi.org/10.1016/s1074-7613(00)80290-3

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S1074761300802903/pdf

References

Articles referenced by this article (78)

Positive selection of invariant V alpha 14+ T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells.
Adachi Y, Koseki H, Zijlstra M, Taniguchi M
Proc Natl Acad Sci U S A, (4):1200-1204 1995
MED: 7862661
An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family.
Arase H, Arase N, Ogasawara K, Good RA, Onoe K
Proc Natl Acad Sci U S A, (14):6506-6510 1992
MED: 1378629
Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major.
Belosevic M, Finbloom DS, Van Der Meide PH, Slayter MV, Nacy CA
J Immunol, (1):266-274 1989
MED: 2499629
Mouse NK1+ T cells.
Bendelac A
Curr Opin Immunol, (3):367-374 1995
MED: 7546402
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.
Bendelac A
J Exp Med, (6):2091-2096 1995
MED: 7500054
A subset of CD4+ thymocytes selected by MHC class I molecules.
Bendelac A, Killeen N, Littman DR, Schwartz RH
Science, (5154):1774-1778 1994
MED: 7907820
CD1 recognition by mouse NK1+ T lymphocytes.
Bendelac A, Lantz O, Quimby ME, Yewdell JW, Bennink JR, Brutkiewicz RR
Science, (5212):863-865 1995
MED: 7538697
Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice.
Bix M, Liao NS, Zijlstra M, Loring J, Jaenisch R, Raulet D
Nature, (6307):329-331 1991
MED: 1987491
Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.
Bix M, Coles M, Raulet D
J Exp Med, (3):901-908 1993
MED: 8350060
Natural T cells. Cells that co-express NKRP-1 and TCR.
Bix M, Locksley RM
J Immunol, (3):1020-1022 1995
MED: 7636176

Show 10 more references (10 of 78)

Citations & impact

Impact metrics

426

Citations

Jump to Citations

13

Data citations

Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/41960017

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/41960017

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/s1074-7613(00)80290-3

Supporting

Mentioning

Contrasting

13

452

0

Article citations

Role of innate T cells in necrotizing enterocolitis.
Liu J, Joseph S, Manohar K, Lee J, Brokaw JP, Shelley WC, Markel TA
Front Immunol, 15:1357483, 08 Feb 2024
Cited by: 0 articles | PMID: 38390341 | PMCID: PMC10881895
Review
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Intrinsic factors and CD1d1 but not CD1d2 expression levels control invariant natural killer T cell subset differentiation.
Amable L, Ferreira Martins LA, Pierre R, Do Cruseiro M, Chabab G, Sergé A, Kergaravat C, Delord M, Viret C, Jaubert J, Liu C, Karray S, Marie JC, Irla M, Georgiev H, Clave E, Toubert A, Lucas B, Klibi J, Benlagha K
Nat Commun, 14(1):7922, 01 Dec 2023
Cited by: 2 articles | PMID: 38040679 | PMCID: PMC10692182
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Effects of NKT Cells on Metabolic Disorders Caused by High-Fat Diet Using CD1d-Knockout Mice.
Ishikawa H, Nagashima R, Kuno Y, Sasaki H, Kohda C, Iyoda M
Diabetes Metab Syndr Obes, 16:2855-2864, 19 Sep 2023
Cited by: 0 articles | PMID: 37744699 | PMCID: PMC10517681
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
The role of Raptor in lymphocytes differentiation and function.
Tang J, Yang L, Guan F, Miller H, Camara NOS, James LK, Benlagha K, Kubo M, Heegaard S, Lee P, Lei J, Zeng H, He C, Zhai Z, Liu C
Front Immunol, 14:1146628, 22 May 2023
Cited by: 0 articles | PMID: 37283744 | PMCID: PMC10239924
Review
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Role of NKT cells in cancer immunotherapy-from bench to bed.
Bayatipoor H, Mehdizadeh S, Jafarpour R, Shojaei Z, Pashangzadeh S, Motallebnezhad M
Med Oncol, 40(1):29, 02 Dec 2022
Cited by: 5 articles | PMID: 36460881
Review

Go to all (426) article citations

Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

The Rat Genome Database (RGD) was established in 1999 and rapidly became the premier site for genetic, genomic, phenotype, and disease-related data generated from rat research. In addition, RGD has expanded to include a large body of structured and standardized data for eight species (rat, mouse, human, chinchilla, bonobo, 13-lined ground squirrel, dog and pig). Much of this data is the result of manual curation work by RGD curators. In other instances, it has been imported into RGD from other databases through custom ELT (Extract, Load and Transform) pipelines giving RGD users integrated access to a wide variety of data to support their research efforts. RGD also offers a growing suite of innovative tools for querying, analyzing and visualizing this data making it a valuable resource for researchers worldwide.

https://rgd.mcw.edu/rgdweb/report/reference/main.html?id=11341406

Funding

Funders who supported this work.

NHLBI NIH HHS (1)

Grant ID: HL54977-01
1 publication

Search life-sciences literature (45,104,206 articles, preprints and more)

CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.

Author information

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Data

Data that cites the article

Gene Ontology Annotation Project

Proteins in UniProt (Showing 5 of 81)

Mouse Genome Informatics (MGI)

Similar Articles

Funding

NHLBI NIH HHS (1)﻿

Partnerships & funding

NHLBI NIH HHS (1)