Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.

Ozçelik H; Schmocker B; Di Nicola N; Shi XH; Langer B; Moore M; Taylor BR; Narod SA; Darlington G; Andrulis IL; Gallinger S; Redston M

doi:10.1038/ng0597-17

Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.

Shi XH ,

Nature Genetics, 01 May 1997, 16(1):17-18
https://doi.org/10.1038/ng0597-17 PMID: 9140390

Abstract

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References

Articles referenced by this article (15)

Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2.
Roa BB, Boyd AA, Volcik K, Richards CS
Nat Genet, (2):185-187 1996
MED: 8841191
The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%.
Oddoux C, Struewing JP, Clayton CM, Neuhausen S, Brody LC, Kaback M, Haas B, Norton L, Borgen P, Jhanwar S, Goldgar D, Ostrer H, Offit K
Nat Genet, (2):188-190 1996
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Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer.
FitzGerald MG, MacDonald DJ, Krainer M, Hoover I, O'Neil E, Unsal H, Silva-Arrieto S, Finkelstein DM, Beer-Romero P, Englert C, Sgroi DC, Smith BL, Younger JW, Garber JE, Duda RB, Mayzel KA, Isselbacher KJ, Friend SH, Haber DA
N Engl J Med, (3):143-149 1996
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Germline BRCA1 185delAG mutations in Jewish women with breast cancer.
Offit K, Gilewski T, McGuire P, Schluger A, Hampel H, Brown K, Swensen J, Neuhausen S, Skolnick M, Norton L, Goldgar D
Lancet, (9016):1643-1645 1996
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Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer.
Neuhausen S, Gilewski T, Norton L, Tran T, McGuire P, Swensen J, Hampel H, Borgen P, Brown K, Skolnick M, Shattuck-Eidens D, Jhanwar S, Goldgar D, Offit K
Nat Genet, (1):126-128 1996
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Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families.
Tonin P, Weber B, Offit K, Couch F, Rebbeck TR, Neuhausen S, Godwin AK, Daly M, Wagner-Costalos J, Berman D, Grana G, Fox E, Kane MF, Kolodner RD, Krainer M, Haber DA, Struewing JP, Warner E, Rosen B, [...] Garber JE
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Identification of the breast cancer susceptibility gene BRCA2.
Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G
Nature, (6559):789-792 1995
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A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes.
Thorlacius S, Olafsdottir G, Tryggvadottir L, Neuhausen S, Jonasson JG, Tavtigian SV, Tulinius H, Ogmundsdottir HM, Eyfjord JE
Nat Genet, (1):117-119 1996
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BRCA2 germline mutations in male breast cancer cases and breast cancer families.
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Nat Genet, (1):123-125 1996
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Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families.
Phelan CM, Lancaster JM, Tonin P, Gumbs C, Cochran C, Carter R, Ghadirian P, Perret C, Moslehi R, Dion F, Faucher MC, Dole K, Karimi S, Foulkes W, Lounis H, Warner E, Goss P, Anderson D, Larsson C, [...] Futreal PA
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The role of germline BRCA1 & BRCA2 mutations in familial pancreatic cancer: A systematic review and meta-analysis.
Limijadi EKS, Muniroh M, Prajoko YW, Tjandra KC, Respati DRP
PLoS One, 19(5):e0299276, 29 May 2024
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Understanding the Genetic Landscape of Pancreatic Ductal Adenocarcinoma to Support Personalized Medicine: A Systematic Review.
Pantaleo A, Forte G, Fasano C, Lepore Signorile M, Sanese P, De Marco K, Di Nicola E, Latrofa M, Grossi V, Disciglio V, Simone C
Cancers (Basel), 16(1):56, 21 Dec 2023
Cited by: 2 articles | PMID: 38201484 | PMCID: PMC10778202
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Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeast.
Palihati M, Iwasaki H, Tsubouchi H
Life Sci Alliance, 7(2):e202302342, 28 Nov 2023
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Pancreatic Cancer: BRCA Targeted Therapy and Beyond.
Keane F, O'Connor CA, Park W, Seufferlein T, O'Reilly EM
Cancers (Basel), 15(11):2955, 28 May 2023
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Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.
Ardeshna DR, Rangwani S, Cao T, Pawlik TM, Stanich PP, Krishna SG
Biomedicines, 10(7):1475, 22 Jun 2022
Cited by: 12 articles | PMID: 35884779 | PMCID: PMC9313108
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Data

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Diseases in OMIM (2)

BRCA2 GENE; BRCA2(OMIM - 600185)
PANCREATIC CANCER, SUSCEPTIBILITY TO, 2(OMIM - 613347)

Proteins in UniProt

Breast cancer type 2 susceptibility protein(UniProt - P51587)

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

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Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients.

Abstract

Full text links

References

Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2.

The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%.

Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer.

Germline BRCA1 185delAG mutations in Jewish women with breast cancer.

Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer.

Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families.

Identification of the breast cancer susceptibility gene BRCA2.

A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes.

BRCA2 germline mutations in male breast cancer cases and breast cancer families.

Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

The role of germline BRCA1 & BRCA2 mutations in familial pancreatic cancer: A systematic review and meta-analysis.

Understanding the Genetic Landscape of Pancreatic Ductal Adenocarcinoma to Support Personalized Medicine: A Systematic Review.

Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeast.

Pancreatic Cancer: BRCA Targeted Therapy and Beyond.

Intraductal Papillary Mucinous Neoplasms in Hereditary Cancer Syndromes.

Data

Data that cites the article

Diseases in OMIM (2)

Proteins in UniProt

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