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Signalling through the lipid products of phosphoinositide-3-OH kinase.

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Affiliations

  • 1. Boston Biomedical Research Institute, Massachusetts 02114, USA.
      Authors
    • Toker A 1
    (1 author)

ORCIDs linked to this article

Nature, 01 Jun 1997, 387(6634):673-676
https://doi.org/10.1038/42648 PMID: 9192891 

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Abstract 

When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.

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Funding 

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NIGMS NIH HHS (1)