Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

Ericson J; Rashbass P; Schedl A; Brenner-Morton S; Kawakami A; van Heyningen V; Jessell TM; Briscoe J

doi:10.1016/s0092-8674(00)80323-2

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

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1. Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Authors
Ericson J¹
(1 author)

ORCIDs linked to this article

Cell, 01 Jul 1997, 90(1):169-180
https://doi.org/10.1016/s0092-8674(00)80323-2 PMID: 9230312

Abstract

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.

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References

Articles referenced by this article (51)

Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain.
Barth KA, Wilson SW
Development, (6):1755-1768 1995
MED: 7600991
Quantitative analysis of cervical musculature in rats: histochemical composition and motor pool organization. II. Deep dorsal muscles.
Callister RJ, Brichta AM, Peterson EH
J Comp Neurol, (3):369-385 1987
MED: 2950140
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA
Nature, (6599):407-413 1996
MED: 8837770
Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum.
Davis CA, Holmyard DP, Millen KJ, Joyner AL
Development, (2):287-298 1991
MED: 1680044
Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons.
Dodd J, Morton SB, Karagogeos D, Yamamoto M, Jessell TM
Neuron, (2):105-116 1988
MED: 3272160
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.
Ekker SC, Ungar AR, Greenstein P, von Kessler DP, Porter JA, Moon RT, Beachy PA
Curr Biol, (8):944-955 1995
MED: 7583153
Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1.
Ericson J, Thor S, Edlund T, Jessell TM, Yamada T
Science, (5063):1555-1560 1992
MED: 1350865
Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube.
Ericson J, Muhr J, Placzek M, Lints T, Jessell TM, Edlund T
Cell, (5):747-756 1995
MED: 7774016
Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity.
Ericson J, Morton S, Kawakami A, Roelink H, Jessell TM
Cell, (4):661-673 1996
MED: 8929535
Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein JL, Tessier-Lavigne M
Mol Cell Neurosci, (1):1-16 1996
MED: 8812055

Show 10 more references (10 of 51)

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Human Frontier Science Program

Medical Research Council (1)

Genes, environment and evolution in eye development and malformations
Professor Veronica van Heyningen, MRC Human Genetics Unit
Grant ID: MC_U127527199
155 publications

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Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

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Xenbase is a model organism database, providing bioinformatics resources, as well as genomic and biological data on Xenopus laevis and Xenopus tropicalis frogs.

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ALS Association

Howard Hughes Medical Institute

Human Frontier Science Program

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National Institutes of Health

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