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Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila.

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Affiliations

  • 1. Department of Biology, York University, 4700 Keele Street, North York, Toronto, Ontario, Canada, M3J 1P3.
      Authors
    • Osborne KA 1
    (1 author)

ORCIDs linked to this article

Science, 01 Aug 1997, 277(5327):834-836
https://doi.org/10.1126/science.277.5327.834 PMID: 9242616 

This is a comment on "What makes fruit flies roam?" Science. 1997 Aug 8;277(5327):763-4.

Abstract 

Naturally occuring polymorphisms in behavior are difficult to map genetically and thus are refractory to molecular characterization. An exception is the foraging gene (for), a gene that has two naturally occurring variants in Drosophila melanogaster food-search behavior: rover and sitter. Molecular mapping placed for mutations in the dg2 gene, which encodes a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG). Rovers had higher PKG activity than sitters, and transgenic sitters expressing a dg2 complementary DNA from rover showed transformation of behavior to rover. Thus, PKG levels affected food-search behavior, and natural variation in PKG activity accounted for a behavioral polymorphism.

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Read article at publisher's site: https://doi.org/10.1126/science.277.5327.834

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