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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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Affiliations

  • 1. Institute for Genetics, University of Cologne, Federal Republic of Germany.
      Authors
    • Lam KP 1
    (1 author)

ORCIDs linked to this article

Cell, 01 Sep 1997, 90(6):1073-1083
https://doi.org/10.1016/s0092-8674(00)80373-6 PMID: 9323135 

A comment on this article appears in "Antigen receptor signaling gives lymphocytes a long life." Cell. 1997 Sep 19;90(6):971-3.

Abstract 

Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen receptor (BCR) marks checkpoints in early B cell development that the cells have to pass to survive. To investigate whether the persistence of mature B cells in the peripheral immune system also depends on BCR expression, we have generated a transgenic mouse in which the BCR can be inducibly ablated through V region gene deletion. Ablation leads to rapid death of mature B lymphocytes, which is preceded by down-regulation of MHC antigens and up-regulation of CD95 (Fas) and can be delayed by constitutive bcl-2 expression.

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Read article at publisher's site: https://doi.org/10.1016/s0092-8674(00)80373-6

Read article for free, from open access legal sources, via Unpaywall: http://www.cell.com/article/S0092867400803736/pdfUnpaywall

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