Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

Cui J; Shin T; Kawano T; Sato H; Kondo E; Toura I; Kaneko Y; Koseki H; Kanno M; Taniguchi M

doi:10.1126/science.278.5343.1623

Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

Shin T ,

Sato H ,

Affiliations

1. Core Research for Evolutional Science and Technology (CREST) Project, Japan Science and Technology Corporation (JST), 1-8-1 Inohana, Chuo-ku, Chiba, Japan 260.
Authors
Cui J¹
(1 author)

ORCIDs linked to this article

Science, 01 Nov 1997, 278(5343):1623-1626
https://doi.org/10.1126/science.278.5343.1623 PMID: 9374462

Abstract

A lymphocyte subpopulation, the Valpha14 natural killer T (NKT) cells, expresses both NK1.1 and a single invariant T cell receptor encoded by the Valpha14 and Jalpha281 gene segments. Mice with a deletion of the Jalpha281 gene segment were found to exclusively lack this subpopulation. The Valpha14 NKT cell-deficient mice could no longer mediate the interleukin-12 (IL-12)-induced rejection of tumors. Although the antitumor effect of IL-12 was thought to be mediated through natural killer cells and T cells, Valpha14 NKT cells were found to be an essential target of IL-12, and they mediated their cytotoxicity by an NK-like effector mechanism after activation with IL-12.

Full text links

Read article at publisher's site: https://doi.org/10.1126/science.278.5343.1623

References

Articles referenced by this article (51)

A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.
Fowlkes BJ, Kruisbeek AM, Ton-That H, Weston MA, Coligan JE, Schwartz RH, Pardoll DM
Nature, (6136):251-254 1987
MED: 3114646
Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.
Budd RC, Miescher GC, Howe RC, Lees RK, Bron C, MacDonald HR
J Exp Med, (2):577-582 1987
MED: 3496420
Extrathymic development of V alpha 14-positive T cells.
Makino Y, Yamagata N, Sasho T, Adachi Y, Kanno R, Koseki H, Kanno M, Taniguchi M
J Exp Med, (5):1399-1408 1993
MED: 8386744
Development of Valpha4+ NK T cells in the early stages of embryogenesis.
Makino Y, Kanno R, Koseki H, Taniguchi M
Proc Natl Acad Sci U S A, (13):6516-6520 1996
MED: 8692847
NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset.
Ballas ZK, Rasmussen W
J Immunol, (4):1039-1045 1990
MED: 1696293
; M. Sykes, ibid., p. 3209; H. I. Levitsky, P. T. Golumbek, D. M. Pardoll, ibid. 146, 1113 (1991);
Y. Takahama, A. Kosugi, A. Singer, ibid., p. 1134; S. Koyasu et al., J. Exp. Med. 175, 203 (1992);
M. Bix, M. Coles, D. Raulet, ibid. 178, 901 (1993);
A subset of CD4+ thymocytes selected by MHC class I molecules.
Bendelac A, Killeen N, Littman DR, Schwartz RH
Science, (5154):1774-1778 1994
MED: 7907820
Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.
Ohteki T, MacDonald HR
J Exp Med, (2):699-704 1994
MED: 8046344

Show 10 more references (10 of 51)

Citations & impact

Impact metrics

856

Citations

Jump to Citations

Data citations

Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/2624330

Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/2624330

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1126/science.278.5343.1623

Supporting

Mentioning

Contrasting

995

Article citations

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers.
Kenney RT, Cini JK, Dexter S, DaFonseca M, Bingham J, Kuan I, Chawla SP, Polasek TM, Lickliter J, Ryan PJ
Front Immunol, 15:1362775, 29 Feb 2024
Cited by: 0 articles | PMID: 38487528
NKT cells in the antitumor response: the β version?
Kronenberg M, Engel I
J Clin Invest, 134(4):e177663, 15 Feb 2024
Cited by: 0 articles | PMID: 38357925 | PMCID: PMC10866647
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Enhancement of Macrophage Immunity against Chlamydial Infection by Natural Killer T Cells.
Peng Y, Qiao S, Wang H, Shekhar S, Wang S, Yang J, Fan Y, Yang X
Cells, 13(2):133, 11 Jan 2024
Cited by: 0 articles | PMID: 38247825 | PMCID: PMC10813948
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion.
Díaz-Basabe A, Lattanzi G, Perillo F, Amoroso C, Baeri A, Farini A, Torrente Y, Penna G, Rescigno M, Ghidini M, Cassinotti E, Baldari L, Boni L, Vecchi M, Caprioli F, Facciotti F, Strati F
Gut Microbes, 16(1):2388801, 01 Jan 2024
Cited by: 0 articles | PMID: 39132842 | PMCID: PMC11321422
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC
Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice.
Han SM, Park ES, Park J, Nahmgoong H, Choi YH, Oh J, Yim KM, Lee WT, Lee YK, Jeon YG, Shin KC, Huh JY, Choi SH, Park J, Kim JK, Kim JB
Nat Commun, 14(1):8512, 21 Dec 2023
Cited by: 1 article | PMID: 38129377 | PMCID: PMC10739728
This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC

Go to all (856) article citations

Data

Data that cites the article

This data has been provided by curated databases and other sources that have cited the article.

Proteins in UniProt (Showing 5 of 6)

TNFR-Cys domain-containing protein(UniProt - A2A887)
TNFR-Cys domain-containing protein(UniProt - Q8R037)
Tumor necrosis factor receptor superfamily member 9(UniProt - P20334)
TNFR-Cys domain-containing protein(UniProt - Q3U3R1)
TNFR-Cys domain-containing protein(UniProt - A2A886)

Go to all (6) records in UniProt

Mouse Genome Informatics (MGI)

http://www.informatics.jax.org/reference/9374462

Search life-sciences literature (45,104,206 articles, preprints and more)

Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

Extrathymic development of V alpha 14-positive T cells.

Development of Valpha4+ NK T cells in the early stages of embryogenesis.

NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset.

; M. Sykes, ibid., p. 3209; H. I. Levitsky, P. T. Golumbek, D. M. Pardoll, ibid. 146, 1113 (1991);

Y. Takahama, A. Kosugi, A. Singer, ibid., p. 1134; S. Koyasu et al., J. Exp. Med. 175, 203 (1992);

M. Bix, M. Coles, D. Raulet, ibid. 178, 901 (1993);

A subset of CD4+ thymocytes selected by MHC class I molecules.

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1126/science.278.5343.1623

Article citations

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers.

NKT cells in the antitumor response: the β version?

Enhancement of Macrophage Immunity against Chlamydial Infection by Natural Killer T Cells.

Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion.

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice.

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 6)

Mouse Genome Informatics (MGI)

Similar Articles

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.

Differential tumor surveillance by natural killer (NK) and NKT cells.

Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Valpha14 NKT cells.

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

Partnerships & funding

Similar Articles

Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells.

Differential tumor surveillance by natural killer (NK) and NKT cells.

Inhibition of tumor metastasis by adoptive transfer of IL-12-activated Valpha14 NKT cells.
Int J Cancer, 91(4):523-528, 01 Feb 2001

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.
Annu Rev Immunol, 21:483-513, 19 Dec 2001

Search life-sciences literature (45,104,206 articles, preprints and more)

Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors.

Author information

Affiliations

Authors

ORCIDs linked to this article

Abstract

Full text links

References

; M. Sykes, ibid., p. 3209; H. I. Levitsky, P. T. Golumbek, D. M. Pardoll, ibid. 146, 1113 (1991);

Y. Takahama, A. Kosugi, A. Singer, ibid., p. 1134; S. Koyasu et al., J. Exp. Med. 175, 203 (1992);

M. Bix, M. Coles, D. Raulet, ibid. 178, 901 (1993);

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Article citations

Data

Data that cites the article

Proteins in UniProt (Showing 5 of 6)

Mouse Genome Informatics (MGI)

Similar Articles

Partnerships & funding