Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Restoration of T-cell homeostasis after T-cell depletion.

Author information

Affiliations

  • 1. Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
      Authors
    • Mackall CL 1
    (1 author)

Seminars in Immunology, 01 Dec 1997, 9(6):339-346
https://doi.org/10.1006/smim.1997.0091 PMID: 9405262 

Review

Abstract 

T-cell homeostasis appears to be maintained throughout much of normal adult life independent of de-novo production from hematopoietic stem cells via thymopoiesis. Instead, peripheral mechanisms are generally sufficient to maintain normal T-cell number, function and adequate TCR repertoire diversity in healthy hosts. Studies of T-cell regeneration in animals, however, have shown that full restoration of T-cell homeostasis after profound T-cell depletion is primarily dependent upon thymopoiesis. In this setting, thymic-deficient hosts have prolonged reductions in total T-cell number, restricted TCR repertoire diversity, and limited immunocompetence. In humans, age-related reductions in thymic regenerative capacity as early as young adulthood result in incomplete restoration of T-cell homeostasis after T-cell depletion.

Full text links 

Read article at publisher's site: https://doi.org/10.1006/smim.1997.0091

Citations & impact 

Impact metrics

133
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/10411554
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/10411554

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1006/smim.1997.0091

Supporting
Mentioning
Contrasting
3
147
1

Article citations

Go to all (133) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.