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The peripheral T-cell pool: regulation by non-antigen induced proliferation?

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Affiliations

  • 1. Immunology Research Group, Biological Sciences, Manchester University Medical School, Manchester, M13 9PT, UK.
      Authors
    • Bell EB 1
    (1 author)

Seminars in Immunology, 01 Dec 1997, 9(6):347-353
https://doi.org/10.1006/smim.1997.0092 PMID: 9405263 

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Abstract 

Despite continuous perturbations, the recirculating lymphocyte pool remains relatively constant. Expansion of the pool is compensated for by cell loss. When the T-cell pool is in deficit, either from a congenital defect or an acquired immunodeficiency, T-cell numbers are restored by extrathymic division-a response that occurs without deliberate provocation. We have considered how the recirculating pool may be stably maintained and how a T-cell deficit might be restored to equilibrium. Recent evidence suggests that depleted T-cell compartments are replenished by CD4 T-cell proliferation in the absence of specific antigen, a response that occurs without engaging the T-cell receptor.

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Read article at publisher's site: https://doi.org/10.1006/smim.1997.0092

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