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Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene.

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Affiliations

  • 1. Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
      Authors
    • Xu J 1
    (1 author)

ORCIDs linked to this article

Science, 01 Mar 1998, 279(5358):1922-1925
https://doi.org/10.1126/science.279.5358.1922 PMID: 9506940 

Abstract 

The in vivo biological function of a steroid receptor coactivator was assessed in mice in which the SRC-1 gene was inactivated by gene targeting. Although in both sexes the homozygous mutants were viable and fertile, target organs such as uterus, prostate, testis, and mammary gland exhibited decreased growth and development in response to steroid hormones. Expression of RNA encoding TIF2, a member of the SRC-1 family, was increased in the SRC-1 null mutant, perhaps compensating partially for the loss of SRC-1 function in target tissues. The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone.

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Read article at publisher's site: https://doi.org/10.1126/science.279.5358.1922

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