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CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

Author information

Affiliations

  • 1. Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
      Authors
    • Topham DJ 1
    (1 author)

Journal of Immunology (Baltimore, Md. : 1950), 01 Dec 1997, 159(11):5197-5200
PMID: 9548456 

Abstract 

Influenza virus infection is controlled in CD4-depleted mice that are also defective for the expression of either Fas (Fas-/-) or perforin (P-/-). Virus-immune P+/+ and P-/- CD8+ T cells can thus function in, respectively, a Fas-/- or Fas+/+ lung environment. The obvious question is whether the P-/- CD8+ set is effective in Fas-/- mice, a conclusion that would tend to favor cytokine secretion as the mode of virus clearance. Short term chimeras were made with P-/- bone marrow, P+/+ or P-/- T cells, and Fas+/+ or Fas-/- irradiated recipients. While the P+/+ CD8+ population cleared the virus from Fas+/+ and Fas-/- respiratory epithelium, the P-/- effectors were operational only if there was the potential for Fas to be expressed on radiation-resistant lung cells. Target cell destruction mediated via the Fas or perforin pathways is clearly the primary mechanism used by CD8+ T cells to terminate this viral pneumonia.

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Free to read at www.jimmunol.org
http://www.jimmunol.org/cgi/content/abstract/159/11/5197

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Funding 

Funders who supported this work.

NCI NIH HHS (1)

NIAID NIH HHS (1)