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Gene gun particle-mediated vaccination with plasmid DNA confers protective immunity against rabies virus infection.

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Affiliations

  • 1. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA.
      Authors
    • Lodmell DL 1
    (1 author)

Vaccine, 01 Jan 1998, 16(2-3):115-118
https://doi.org/10.1016/s0264-410x(97)88325-9 PMID: 9607018 

Abstract 

Accell gene gun particle-mediated immunization with DNA encoding the glycoprotein gene of the challenge virus standard strain of rabies virus was evaluated for its ability to elicit protective levels of serum anti-rabies virus neutralizing antibody. Strong primary and booster neutralizing antibody responses were detected in mice following immunization with 2 micrograms of DNA coated on 2.6-micron gold beads. Protective levels of antibody persisted for over 300 days. Mice challenged intraplantarly 315 days post-primary immunization (225 days post-booster vaccination) survived lethal rabies virus challenge. Our data demonstrate a potentially significant role for gene gun-based delivery of DNA in the field of rabies virus vaccination.

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