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Transcriptional factor mutations reveal regulatory complexities of heat shock and newly identified stress genes in Saccharomyces cerevisiae.

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Affiliations

  • 1. Department of Biological Chemistry, UCLA School of Medicine, Center of Health Sciences, University of California, Los Angeles, California 90095, USA.
      Authors
    • Treger JM 1
    (1 author)

ORCIDs linked to this article

The Journal of Biological Chemistry, 01 Oct 1998, 273(41):26875-26879
https://doi.org/10.1074/jbc.273.41.26875 PMID: 9756934 

Abstract 

A computer-aided pattern search of the entire yeast genome was designed and used to identify 186 putative stress response element-regulated genes in Saccharomyces cerevisiae. Transcript levels of eight of these candidate genes were examined, and three (37%) were shown to be heat shock- and DNA damage-inducible and to require the Msn2p and Msn4p transcriptional activators for stress regulation. Significantly, several heat shock protein (HSP) genes were identified in this computer search. Using a series of single and multiple regulatory mutants, we demonstrate unexpected regulatory complexities among the HSP genes from S. cerevisiae following heat shock.

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Read article at publisher's site: https://doi.org/10.1074/jbc.273.41.26875

Read article for free, from open access legal sources, via Unpaywall: http://www.jbc.org/article/S0021925819598246/pdfUnpaywall

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Funding 

Funders who supported this work.

NIGMS NIH HHS (1)