Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

TGF-beta signal transduction.

Author information

Affiliations

  • 1. Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
      Authors
    • Massagué J 1
    (1 author)

ORCIDs linked to this article

Annual Review of Biochemistry, 01 Jan 1998, 67:753-791
https://doi.org/10.1146/annurev.biochem.67.1.753 PMID: 9759503 

Review

Abstract 

The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-beta signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-beta and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.

Full text links 

Read article at publisher's site: https://doi.org/10.1146/annurev.biochem.67.1.753

Read article for free, from open access legal sources, via Unpaywall: https://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.67.1.753Unpaywall

References 

Articles referenced by this article (297)

Show 10 more references (10 of 297)

Citations & impact 

Impact metrics

2,783
Citations
Jump to Citations
12
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/3373256
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/3373256

Article citations

Go to all (2,783) article citations

Other citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.