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Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells.

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Affiliations

  • 1. Department of Biochemistry, National Public Health Institute, Mannerheimintie 166, Helsinki, 00300, Finland.
      Authors
    • Ikonen E 1
    (1 author)

ORCIDs linked to this article

Seminars in Cell & Developmental Biology, 01 Oct 1998, 9(5):503-509
https://doi.org/10.1006/scdb.1998.0258 PMID: 9835637 

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Abstract 

The targeting of proteins and lipids to the cell surface domains of polarized cells is not a simple bulk flow process but requires sorting into distinct apical and basolateral pathways from the trans-Golgi network. Here, we describe the sorting determinants in the cargo molecules, the cellular sorting machineries responsible for the hierarchical read-out of the signals, and the mechanisms of cargo delivery. Furthermore, we discuss the implications of these findings for protein-lipid interactions in other cellular machineries.

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Read article at publisher's site: https://doi.org/10.1006/scdb.1998.0258

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