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A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.

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Affiliations

  • 1. Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA. wood@stripe. colorado.edu
      Authors
    • Suzuki Y 1
    (1 author)

Development (Cambridge, England), 01 Jan 1999, 126(2):241-250
https://doi.org/10.1242/dev.126.2.241 PMID: 9847238 

Abstract 

We cloned the dbl-1 gene, a C. elegans homolog of Drosophila decapentaplegic and vertebrate BMP genes. Loss-of-function mutations in dbl-1 cause markedly reduced body size and defective male copulatory structures. Conversely, dbl-1 overexpression causes markedly increased body size and partly complementary male tail phenotypes, indicating that DBL-1 acts as a dose-dependent regulator of these processes. Evidence from genetic interactions indicates that these effects are mediated by a Smad signaling pathway, for which DBL-1 is a previously unidentified ligand. Our study of the dbl-1 expression pattern suggests a role for neuronal cells in global size regulation as well as male tail patterning.

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Read article at publisher's site: https://doi.org/10.1242/dev.126.2.241

Free to read at dev.biologists.org
http://dev.biologists.org/cgi/content/abstract/126/2/241

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