RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells.

Wu L; D'Amico A; Winkel KD; Suter M; Lo D; Shortman K

doi:10.1016/s1074-7613(00)80649-4

RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells.

Lo D ,

Affiliations

1. The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.
Authors
Wu L¹
(1 author)

ORCIDs linked to this article

Winkel KD | 0000-0001-8282-6938

Immunity, 01 Dec 1998, 9(6):839-847
https://doi.org/10.1016/s1074-7613(00)80649-4 PMID: 9881974

Abstract

The transcription factor RelB had been shown to be important for dendritic cell (DC) development, but the type of DC involved was not clear. Here, we report that RelB mRNA is expressed strongly in CD8alpha- DEC-205- DC but only weakly in CD8alpha+ DEC-205+ DC. In addition, CD8alpha+ DEC-205+ DC are present and functional in RelB null mice, the DC deficiency being mainly in the CD8alpha- DEC-205- population. By constructing bone-marrow chimeric mice, we demonstrate that the partial deficiency in RelB null thymic DC is a secondary effect of disrupted thymic architecture. However, the deficiency in splenic CD8alpha- DEC-205- DC is a direct, stem cell intrinsic effect of the RelB mutation. Thus, RelB selectively regulates a myeloid-related DC lineage.

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Proteins in UniProt (Showing 5 of 10)

RHD domain-containing protein(UniProt - A0A140LI46)
RHD domain-containing protein(UniProt - Q8K220)
RHD domain-containing protein(UniProt - A0A140LJD6)
Transcription factor RelB(UniProt - Q04863)
RHD domain-containing protein(UniProt - Q4U109)

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Mouse Genome Informatics (MGI)

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