The HIV-1 Rev protein.

Pollard VW; Malim MH

doi:10.1146/annurev.micro.52.1.491

Abstract

The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal. These essential peptide motifs have now been shown to function by accessing cellular signal-mediated pathways for nuclear import and nuclear export. HIV-1 Rev therefore represents an excellent system with which to study aspects of transport across the nuclear envelope.

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References

Articles referenced by this article (239)

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The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting.
Roesmann F, Sertznig H, Klaassen K, Wilhelm A, Heininger D, Heß S, Elsner C, Marschalek R, Santiago ML, Esser S, Sutter K, Dittmer U, Widera M
J Virol, 98(7):e0053424, 20 Jun 2024
Cited by: 1 article | PMID: 38899932
Structure of HIV-1 RRE stem-loop II identifies two conformational states of the high-affinity Rev binding site.
Tipo J, Gottipati K, Slaton M, Gonzalez-Gutierrez G, Choi KH
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Cited by: 0 articles | PMID: 38787201 | PMCID: PMC11124504
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing.
Yandrapally S, Sarkar S, Banerjee S
J Virol, 97(11):e0104423, 31 Oct 2023
Cited by: 2 articles | PMID: 37905837 | PMCID: PMC10688328
Free full text in Europe PMC
Retroviral hijacking of host transport pathways for genome nuclear export.
Behrens RT, Sherer NM
mBio, 14(6):e0007023, 01 Nov 2023
Cited by: 2 articles | PMID: 37909783 | PMCID: PMC10746203
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The HIV-1 Rev protein.

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References

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery.

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1.

Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm.

Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.

HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.

Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex.

Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A.

Finding splice sites within a wilderness of RNA.

Citations & impact

Impact metrics

Citations of article over time

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Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1146/annurev.micro.52.1.491

Article citations

The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting.

Structure of HIV-1 RRE stem-loop II identifies two conformational states of the high-affinity Rev binding site.

Co-Infections and Superinfections between HIV-1 and Other Human Viruses at the Cellular Level.

HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing.

Retroviral hijacking of host transport pathways for genome nuclear export.

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Wikipedia (3)

Data

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The HIV-1 Rev protein.

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