Extended Data Fig. 1

a, Donor diversity is calculated for every cluster as entropy of donor proportions in the cluster, with high entropy indicating the cluster contains cells from many different donors. Most clusters (80 out of 94) contain cells from many donors (median 47 donors per cluster, range 2–102), as illustrated by high donor entropy (>0.43), whereas 14 clusters show low donor diversity. These are largely immune cell clusters (n=13, of which 7 macrophage clusters, 4 T cell clusters and 2 mast cell clusters), representing donor- or group-specific phenotypes. Matching cell type annotations are shown in Fig. ​Fig.3d.3d. b, Marker expression among cells from the immune cluster with highest disagreement in original cell type labels (high ‘label entropy’). DC2, monocyte and macrophage marker expression is shown for cells from Fig. ​Fig.3c.3c. Cells are labeled by their final annotation, as well as their original label. Log-normalized counts are scaled such that for each gene the 99th expression percentile, as calculated among all cells included in the heatmap, is set to 1. DC: dendritic cell.