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DUXAP8 expression is increased in preeclamptic placentae and primarily located in the nucleus of HTR-8/SVneo and JAR cells. A-B Heat map and volcano plot of the most differentially expressed lncRNAs in the placental tissues between the PE (n = 5, preeclampsia) and CTR (n = 5, normal control) group. C Validated expression of DUXAP8 in placentae of PE (n = 40) and CTR (n = 46) group was detected by RT-qPCR. Data are presented as the mean ± SEM, and statistical significance was evaluated using t-test for 2 comparisons. D The distribution and expression of DUXAP8 in the placental villi of CTR and PE group were detected by RNA-FISH (scar bar = 50 μm) (DAPI: nucleus; CK7: Cytokeratin 7, trophoblast marker protein). E-F Intracellular localization of DUXAP8 in HTR8/SVneo and JAR cells was observed by RNA-FISH (scar bar = 10 μm) (U6: nuclear marker; 18 S/β-actin: cytoplasmic marker) and cell fractionation assays (n = 3, Data are presented as the percentage)

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