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Cell-matrix contact structures.

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  • 1. Department of Biochemistry and Molecular Biology, University College London, UK.
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    • Adams JC 1
    (1 author)

Cellular and Molecular Life Sciences : CMLS, 01 Mar 2001, 58(3):371-392
https://doi.org/10.1007/pl00000864 PMID: 11315186 PMCID: PMC11337345

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Abstract 

Cell-extracellular matrix contacts are points on cell surfaces where adhesion receptors tether cells to matrix and are linked intracellularly to cytoskeletal components. These structures integrate cell organisation within tissues, support cell motility and specialised activities of differentiated cells, and transduce extracellular signals. Current characterisations of matrix contacts are based on morphological and biochemical criteria, yet the levels of definition of different contact types are very varied. Some contacts are surprisingly little-studied given their likely importance in vivo. Here, I describe the general features of matrix contacts, review the functions and molecular composition of major types of transient and stable matrix contacts, and discuss the information that is emerging on contact integration and dynamics in single cells.

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Cell Mol Life Sci. 2001 Mar; 58(3): 371–392.
PMCID: PMC11337345
PMID: 11315186

Cell-matrix contact structures

J.C. Adams
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Abstract:

Cell-extracellular matrix contacts are points on cell surfaces where adhesion receptors tether cells to matrix and are linked intracellularly to cytoskeletal components. These structures integrate cell organisation within tissues, support cell motility and specialised activities of differentiated cells, and transduce extracellular signals. Current characterisations of matrix contacts are based on morphological and biochemical criteria, yet the levels of definition of different contact types are very varied. Some contacts are surprisingly little-studied given their likely importance in vivo. Here, I describe the general features of matrix contacts, review the functions and molecular composition of major types of transient and stable matrix contacts, and discuss the information that is emerging on contact integration and dynamics in single cells.

Keywords: Key words: Extracellular matrix; cell adhesion; filopodia; podosome; focal adhesion; matrix assembly; signalling.

Footnotes

Received 7 September 2000; received after revision 4 October 2000; accepted 6 October 2000

Articles from Cellular and Molecular Life Sciences: CMLS are provided here courtesy of Springer

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