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Figure 5

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Secondary structure content of LC peptide in cetuximab forms. (A) Bar plots showing the per residue secondary structure content in the LC peptide (res. 140-170) of cetuximab (top) and cetuximab without Fab glycosylation (bottom). The frequency of each secondary structure type according to DSSP classification is reported in percent on y-axis. (B) Structural superposition of glycosylated (in blue) and aglycosylated (in gray) Fab domains showing the differences in the secondary structure of LC peptides.

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