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Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3.

Author information

Affiliations

  • 1. https://ror.org/05gq02987 Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
      Authors
    • Lee CM 1
    • He CH 1
    • Park JW 1
    • Kamle S 1
    • Ma B 1
    • Akosman B 1
    • Cortez R 1
    • Chen E 1
    • Zhou Y 1
    • Elias JA 1
    (10 authors)
  • 2. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
      Authors
    • Lee JH 2
    • Ryu C 2
    • Peng X 2
    (3 authors)
  • 3. Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
      Authors
    • Herzog EL 3
    (1 author)
  • 4. Brigham and Women's Hospital, Boston, MA, USA.
      Authors
    • Rosas IO 4
    • Poli S 4
    (2 authors)
  • 5. https://ror.org/012jban78 Department of Medicine, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
      Authors
    • Bostwick CF 5
    (1 author)
    • Show all (7)

ORCIDs linked to this article

Life Science Alliance, 29 Aug 2024, 7(11):e202402987
https://doi.org/10.26508/lsa.202402987 PMID: 39209538 PMCID: PMC11361373

This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
Free full text in Europe PMC

This retracts "Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3." in Life Sci Alliance. 2019 May 13;2(3):e201900350. doi: 10.26508/lsa.201900350.

Abstract 

No abstract provided.

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Logo of lifesciallLink to Publisher's site
Life Sci Alliance. 2024 Nov; 7(11): e202402987.
Published online 2024 Aug 29. https://doi.org/10.26508/lsa.202402987
PMCID: PMC11361373
PMID: 39209538

Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

Chang-Min Lee,1 Chuan-Hua He,1 Jin Wook Park,1 Jae Hyun Lee,2 Suchitra Kamle,1 Bing Ma,1 Bedia Akosman,1 Roberto Cortez,1 Emily Chen,1 Yang Zhou,1 Erica L Herzog,3 Changwan Ryu,2 Xueyan Peng,2 Ivan O Rosas,4 Sergio Poli,4 Carol Feghali Bostwick,5 Augustine M Choi,6 Jack A Elias,1,7 and Chun Geun Leecorresponding author1
Author information Article notes Copyright and License information Disclaimer

Abstract

Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.

Article: Lee C-M, He C-H, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG (2019 May 13) Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance 2(3): e201900350. 10.26508/lsa.201900350. PMID: 31085559.

The authors wish to retract this article because concerns have been raised regarding the contents and labeling of some of the figures in this article, including Figs 2D, 3A, and 4A. These figures appear to include duplicate data or to incorporate separate experiments that are not accurately labeled. Some of the immunoblot data cannot be verified from the records available. Although we believe that the conclusions of the article are still valid, in light of the inaccuracies in these figures, we consider that the appropriate course of action is to retract the article. All the authors agree with the retraction.

Articles from Life Science Alliance are provided here courtesy of Life Science Alliance LLC

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