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(A) Comparison of the
nosiheptide (nos), nocathiacin
(noc), and putative persiathiacin (per) biosynthetic gene clusters. Genes are colored as follows. Blue:
thiazole formation; green: Ser/Thr dehydration; orange: DMIA formation
and attachment; red: cytochromes P450; gray: 6-deoxysugar biosynthesis
and attachment; brown: methyltransferases. (B) The biosynthesis of
the thiopeptide core of the persiathiacins is proposed to commence
with transcription and translation of perM to yield
a precursor peptide comprised of an N-terminal leader peptide (LP)
fused to a C-terminal core peptide (structure depicted). The core
peptide undergoes a series of post-translational modifications catalyzed
by several enzymes encoded by the persiathiacin biosynthetic gene
cluster. See main text for further details.