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ACS Infectious Diseases
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Figure 3

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(A) Comparison of the nosiheptide (nos), nocathiacin (noc), and putative persiathiacin (per) biosynthetic gene clusters. Genes are colored as follows. Blue: thiazole formation; green: Ser/Thr dehydration; orange: DMIA formation and attachment; red: cytochromes P450; gray: 6-deoxysugar biosynthesis and attachment; brown: methyltransferases. (B) The biosynthesis of the thiopeptide core of the persiathiacins is proposed to commence with transcription and translation of perM to yield a precursor peptide comprised of an N-terminal leader peptide (LP) fused to a C-terminal core peptide (structure depicted). The core peptide undergoes a series of post-translational modifications catalyzed by several enzymes encoded by the persiathiacin biosynthetic gene cluster. See main text for further details.

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