Haploidentical vs HLA-matched sibling donor HCT with PTCy prophylaxis: HLA factors and donor age considerations

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Published online 2024 Aug 23. doi: 10.1182/bloodadvances.2024013853

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Table 3.

Multivariate analysis: younger haploidentical vs older MSD

OS	n	Events	Point estimates	HR	95% CI	P
Older MSD-PTCy	143	80	45.1% (36.5-54.0)	Ref
Younger haplo-PTCy	347	157	57.3 % (52.0-62.5)	0.76	0.57-1.01	.06
Older MSD-PTCy	143	80	45.1% (36.5-54.0)	Ref
Younger haplo: B-leader–matched	222	91	62.1% (55.5-68.4)	0.65	0.48-0.9	.009
Younger haplo: B-leader–mismatched	125	66	48.9% (40.1-57.7)	0.99	0.7-1.39	.95

NRM	n	Events	Point estimates	HR	95% CI	P
Older MSD-PTCy	143	34	23.7% (16.9-31.1)	Ref
Younger haplo-PTCy	340	70	20.1% (16-24.6)	0.96	0.7-1.33	.82
Older MSD-PTCy	143	34	23.7% (16.9-31.1)	Ref
Younger haplo: B-leader–matched	217	42	19% (14.1-24.5)	0.87	0.61-1.23	.43
Younger haplo: B-leader–mismatched	123	28	22.1% (15.2-29.8)	1.12	0.78-1.6	.55

Relapse	n	Events	Point estimates	HR	95% CI	P
Older MSD-PTCy	143	65	44.7% (36.1-52.9)	Ref
Younger haplo-PTCy	340	127	33.7% (28.7-38.8)	0.71	0.52-0.98	.04
Older MSD-PTCy	143	65	44.7% (36.1-52.9)	Ref
Younger haplo: DRB1-mismatched	278	93	30.6% (25.2-36.1)	0.63	0.46-0.87	.004
Younger haplo: DRB1-matched	61	34	48.3% (34.9-60.4)	1.03	0.68-1.57	.88

Chronic GVHD	n	Events	Point estimates	HR	95% CI	P
Older MSD-PTCy	142	47	33.3% (25.4-41.3)	Ref
Younger haplo-PTCy	337	91	26.5% (21.9-31.4)	0.78	0.49-1.25	.31

Acute GVHD, grade 2-4^†	n	Events	Point estimates	HR	95% CI	P
Older MSD-PTCy	143	44	30.8% (23.4-38.5)	Ref
Younger haplo-PTCy	347	97	27.9% (23.4-32.8)	0.90	0.58-1.39	.64

Haplo, haploidentical; Ref, reference.

Stratified by disease stage.

^†Stratified by race.