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Table 2

Number of adult-onset DM1 individuals with each sign and symptom, from MD STARnet (N = 228)

21 Signs and Symptoms a n %
Myotonia18078.9
Facial Weakness/Trouble Smiling14664.0
Distal Weakness14262.3
Hand Weakness13659.6
Proximal Weakness10043.9
Trouble Walking / Running / Jumping9943.4
Ptosis9843.0
Dysarthria9541.7
Hand Stiffness9039.5
Cataracts Before 50 (for all individuals, n = 228) b8939.0
Dysphagia8939.0
Chronic Fatigue8436.8
Daytime Sleepiness c8135.5
Gastrointestinal Distress c7733.8
Sleep Apnea5222.8
Myalgia c4620.2
Trouble Climbing Up & Down Stairs3414.9
Jaw Stiffness3113.6
Cognitive Impairment156.6
Respiratory Failure / Insufficiency< 11NR
Developmental Delays c< 11NR

Notea: the number of patients reporting a symptom is not mutually exclusive. b: Among 69 individuals who are ≥ 50 years old, 31 (44.9%) reported having Cataracts Before 50 years old. c: This term includes a range of signs and symptoms, please refer to the Supplementary Table 2 for detailed information. In factor analysis, only signs and symptoms with over 10 patients were included. NR = no report for signs and symptoms among less than 11 patients