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Stable hairpin structure within the 5'-terminal 85 nucleotides of poliovirus RNA.

Journal of Virology, 01 Jan 1981, 37(1):328-335
https://doi.org/10.1128/jvi.37.1.328-335.1981 PMID: 6260985 PMCID: PMC171010

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Abstract 

The primary sequence of a 5'-terminal fragment of poliovirus type 1 RNA, generated by digestion with RNase III, has been determined. This sequence reveals the presence of a stable hairpin structure beginning nine nucleotides from the terminally linked protein VPg. The sequence does not contain (i) the initiation codons AUG or GUG or (ii) the putative ribosome-binding sequence complementary to the 3' end of eucaryotic ribosomal 18S RNA. The stem-and-loop structure identified can be drawn in either plus or minus RNA strands. It is unclear to which strand functional significance (if any) can be assigned. It is possible that the hairpin structure is involved in ribosomal recognition and translation or in RNA synthesis by interacting with replicase molecules.

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J Virol. 1981 Jan; 37(1): 328–335.
PMCID: PMC171010
PMID: 6260985

Stable hairpin structure within the 5'-terminal 85 nucleotides of poliovirus RNA.

G R Larsen, B L Semler, and E Wimmer
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Abstract

The primary sequence of a 5'-terminal fragment of poliovirus type 1 RNA, generated by digestion with RNase III, has been determined. This sequence reveals the presence of a stable hairpin structure beginning nine nucleotides from the terminally linked protein VPg. The sequence does not contain (i) the initiation codons AUG or GUG or (ii) the putative ribosome-binding sequence complementary to the 3' end of eucaryotic ribosomal 18S RNA. The stem-and-loop structure identified can be drawn in either plus or minus RNA strands. It is unclear to which strand functional significance (if any) can be assigned. It is possible that the hairpin structure is involved in ribosomal recognition and translation or in RNA synthesis by interacting with replicase molecules.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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