Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant Pseudomonas maltophilia.

Author information

Affiliations

  • 1. Department of Medicine, University of British Columbia, Vancouver, Canada.
      Authors
    • Chow AW 1
    (1 author)

Antimicrobial Agents and Chemotherapy, 01 May 1988, 32(5):782-784
https://doi.org/10.1128/aac.32.5.782 PMID: 3395107 PMCID: PMC172276

Free full text in Europe PMC

Abstract 

The susceptibility of 28 clinical isolates of Pseudomonas maltophilia to 16 antimicrobial agents was determined in vitro by a standard agar dilution method with inoculum sizes of 10(4) and 10(6) CFU. All isolates exhibited multiple drug resistance. Nine isolates were selected for studies of combinations of ciprofloxacin with seven antipseudomonal beta-lactams and three aminoglycosides by a checkerboard agar dilution technique. Synergistic or additive combinations of ciprofloxacin in clinically achievable concentrations were most frequent with mezlocillin (89%), followed by cefoperazone (67%), piperacillin (56%), cefsulodin (56%), and ceftazidime (33%), and were infrequent with aztreonam (11%), the aminoglycosides (0 to 14%), or imipenem (0%). Antagonism was not observed in any combination. These data suggest that combinations of ciprofloxacin with these agents may be useful for some nosocomial multiply drug-resistant P. maltophilia infections.

Free full text 

Logo of aacLink to Publisher's site
Antimicrob Agents Chemother. 1988 May; 32(5): 782–784.
PMCID: PMC172276
PMID: 3395107

Synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant Pseudomonas maltophilia.

A W Chow, J Wong, and K H Bartlett
Author information Copyright and License information Disclaimer

Abstract

The susceptibility of 28 clinical isolates of Pseudomonas maltophilia to 16 antimicrobial agents was determined in vitro by a standard agar dilution method with inoculum sizes of 10(4) and 10(6) CFU. All isolates exhibited multiple drug resistance. Nine isolates were selected for studies of combinations of ciprofloxacin with seven antipseudomonal beta-lactams and three aminoglycosides by a checkerboard agar dilution technique. Synergistic or additive combinations of ciprofloxacin in clinically achievable concentrations were most frequent with mezlocillin (89%), followed by cefoperazone (67%), piperacillin (56%), cefsulodin (56%), and ceftazidime (33%), and were infrequent with aztreonam (11%), the aminoglycosides (0 to 14%), or imipenem (0%). Antagonism was not observed in any combination. These data suggest that combinations of ciprofloxacin with these agents may be useful for some nosocomial multiply drug-resistant P. maltophilia infections.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (563K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 782
782
icon of scanned page 783
783
icon of scanned page 784
784
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Blaser J, Dudley MN, Gilbert D, Zinner SH. Influence of medium and method on the in vitro susceptibility of Pseudomonas aeruginosa and other bacteria to ciprofloxacin and enoxacin. Antimicrob Agents Chemother. 1986 May;29(5):927–929. [Europe PMC free article] [Abstract] [Google Scholar]
  • Chan EL, Zabransky RJ. Determination of synergy by two methods with eight antimicrobial combinations against tobramycin-susceptible and tobramycin-resistant strains of Pseudomonas. Diagn Microbiol Infect Dis. 1987 Feb;6(2):157–164. [Abstract] [Google Scholar]
  • Chin NX, Neu HC. Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 1984 Mar;25(3):319–326. [Europe PMC free article] [Abstract] [Google Scholar]
  • Eliopoulos GM, Moellering AE, Reiszner E, Moellering RC., Jr In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620. Antimicrob Agents Chemother. 1985 Oct;28(4):514–520. [Europe PMC free article] [Abstract] [Google Scholar]
  • Fass RJ. In vitro activity of ciprofloxacin (Bay o 9867). Antimicrob Agents Chemother. 1983 Oct;24(4):568–574. [Europe PMC free article] [Abstract] [Google Scholar]
  • Fass RJ, Barnishan J. Minimal inhibitory concentrations of 34 antimicrobial agents for control strains Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. Antimicrob Agents Chemother. 1979 Nov;16(5):622–624. [Europe PMC free article] [Abstract] [Google Scholar]
  • Fass RJ, Helsel VL, Wright CA. Minimal inhibitory concentrations of broad spectrum beta-lactam antibiotics for bacterial control strains. Diagn Microbiol Infect Dis. 1983 Mar;1(1):85–88. [Abstract] [Google Scholar]
  • Felegie TP, Yu VL, Rumans LW, Yee RB. Susceptibility of Pseudomonas maltophilia to antimicrobial agents, singly and in combination. Antimicrob Agents Chemother. 1979 Dec;16(6):833–837. [Europe PMC free article] [Abstract] [Google Scholar]
  • Haller I. Comprehensive evaluation of ciprofloxacin-aminoglycoside combinations against Enterobacteriaceae and Pseudomonas aeruginosa strains. Antimicrob Agents Chemother. 1985 Nov;28(5):663–666. [Europe PMC free article] [Abstract] [Google Scholar]
  • Hirschhorn L, Neu HC. Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620. Antimicrob Agents Chemother. 1986 Jul;30(1):143–146. [Europe PMC free article] [Abstract] [Google Scholar]
  • Holmes B, Lapage SP, Easterling BG. Distribution in clinical material and identification of Pseudomonas maltophilia. J Clin Pathol. 1979 Jan;32(1):66–72. [Europe PMC free article] [Abstract] [Google Scholar]
  • Husson MO, Izard D, Bouillet L, Leclerc H. Comparative in-vitro activity of ciprofloxacin against non-fermenters. J Antimicrob Chemother. 1985 Apr;15(4):457–462. [Abstract] [Google Scholar]
  • Kelley SG, Bertram MA, Young LS. Activity of ciprofloxacin against resistant clinical isolates. J Antimicrob Chemother. 1986 Mar;17(3):281–286. [Abstract] [Google Scholar]
  • Wheat PF, Winstanley TG, Spencer RC. Effect of temperature on antimicrobial susceptibilities of Pseudomonas maltophilia. J Clin Pathol. 1985 Sep;38(9):1055–1058. [Europe PMC free article] [Abstract] [Google Scholar]
  • Yu VL, Felegie TP, Yee RB, Pasculle AW, Taylor FH. Synergistic interaction in vitro with use of three antibiotics simultaneously against Pseudomonas maltophilia. J Infect Dis. 1980 Oct;142(4):602–607. [Abstract] [Google Scholar]
  • Zuravleff JJ, Yu VL, Yee RB, Zaphyr MK, Diven W, Taylor FB. Effect of calcium, magnesium, and zinc on ticarcillin and tobramycin alone and in combination against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1982 Nov;22(5):839–843. [Europe PMC free article] [Abstract] [Google Scholar]
Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

Full text links 

Read article at publisher's site: https://doi.org/10.1128/aac.32.5.782

Read article for free, from open access legal sources, via Unpaywall: https://europepmc.org/articles/pmc172276?pdf=renderUnpaywall

Citations & impact 

Impact metrics

30
Citations
Jump to Citations

Citations of article over time

Article citations

Go to all (30) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.