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Evidence for the inactivation of an X chromosome early in the development of the human female.

American Journal of Human Genetics, 01 Mar 1975, 27(2):233-239
PMID: 1124767 PMCID: PMC1762755

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Abstract 

Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose-6-phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 weeks from conception.

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Logo of ajhgGuide for AuthorsAbout this journalExplore this journalAmerican Journal of Human Genetics
Am J Hum Genet. 1975 Mar; 27(2): 233–239.
PMCID: PMC1762755
PMID: 1124767

Evidence for the inactivation of an X chromosome early in the development of the human female.

B R Migeon and J F Kennedy
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Abstract

Studies of somatic tissues and cultured cells, including fibroblast clones, from human embryos heterozygous for the electrophoretic variants of glucose-6-phosphate dehydrogenase confirm that one X chromosome is inactivated very early in embryonic development and indicate that X inactivation has occurred in the majority of cells from a variety of tissues at least by 5 weeks from conception.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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