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The human gene AHNAK encodes a large phosphoprotein located primarily in the nucleus.

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Affiliations

  • 1. Department of Microbiology and Immunology, University of California, San Francisco 94143.
      Authors
    • Shtivelman E 1
    (1 author)

The Journal of Cell Biology, 01 Feb 1993, 120(3):625-630
https://doi.org/10.1083/jcb.120.3.625 PMID: 8381120 PMCID: PMC2119538

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Abstract 

AHNAK is a newly identified human gene notable for the exceptional size (c.a. 700 kD) and structure of its product, and for the repression of its expression in human neuroblastoma cells. Here we report the identification and partial characterization of the protein encoded by AHNAK. The protein is located principally (but not exclusively) in the nucleus and is phosphorylated on both serine and threonine. The abundance of the protein increases appreciably when cells withdraw from the division cycle, in response to either withdrawal of serum (fibroblasts) or differentiation (neuroblastoma cells). By contrast, the amount of phosphorylation appears to diminish in those settings. The considerable abundance and conjectured fibrous structure of AHNAK protein suggest a role in cytoarchitecture, but no function can yet be discerned.

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J Cell Biol. 1993 Feb 1; 120(3): 625–630.
PMCID: PMC2119538
PMID: 8381120

The human gene AHNAK encodes a large phosphoprotein located primarily in the nucleus

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Abstract

AHNAK is a newly identified human gene notable for the exceptional size (c.a. 700 kD) and structure of its product, and for the repression of its expression in human neuroblastoma cells. Here we report the identification and partial characterization of the protein encoded by AHNAK. The protein is located principally (but not exclusively) in the nucleus and is phosphorylated on both serine and threonine. The abundance of the protein increases appreciably when cells withdraw from the division cycle, in response to either withdrawal of serum (fibroblasts) or differentiation (neuroblastoma cells). By contrast, the amount of phosphorylation appears to diminish in those settings. The considerable abundance and conjectured fibrous structure of AHNAK protein suggest a role in cytoarchitecture, but no function can yet be discerned.

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Selected References

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Funding 

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NCI NIH HHS (1)