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EXPERIMENTAL TRANSMISSION OF INFLUENZA VIRUS INFECTION IN MICE. I. THE PERIOD OF TRANSMISSIBILITY.

The Journal of Experimental Medicine, 01 Aug 1963, 118:257-266
https://doi.org/10.1084/jem.118.2.257 PMID: 14074389 PMCID: PMC2137713

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Abstract 

An experimental model has been developed for the reproducible transmission of influenza virus infection from experimentally infected mice to uninfected cage mates. Infector mice transmit influenza virus infection most readily during the period 24 to 48 hours after initiation of their infection. This restricted period of transmission is not due to declining titers of infective virus in the nose, trachea, or lungs of infector mice after 48 hours of infection, since peak titers in these tissues are maintained for another 48 hours. A mouse-adapted strain of A2 virus was found to be more readily transmitted than the mouse-adapted CAM strain of influenza A1 virus, although the CAM strain induced higher pulmonary virus titers and more extensive lung lesions.

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J Exp Med. 1963 Aug 1; 118(2): 257–266.
PMCID: PMC2137713
PMID: 14074389

EXPERIMENTAL TRANSMISSION OF INFLUENZA VIRUS INFECTION IN MICE

I. THE PERIOD OF TRANSMISSIBILITY
Jerome L. Schulman and Edwin D. Kilbourne
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Abstract

An experimental model has been developed for the reproducible transmission of influenza virus infection from experimentally infected mice to uninfected cage mates. Infector mice transmit influenza virus infection most readily during the period 24 to 48 hours after initiation of their infection. This restricted period of transmission is not due to declining titers of infective virus in the nose, trachea, or lungs of infector mice after 48 hours of infection, since peak titers in these tissues are maintained for another 48 hours. A mouse-adapted strain of A2 virus was found to be more readily transmitted than the mouse-adapted CAM strain of influenza A1 virus, although the CAM strain induced higher pulmonary virus titers and more extensive lung lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. [Abstract] [Google Scholar]
  • LOOSLI CG. The pathogenesis and pathology of experimental air-borne influenza virus A infections in mice. J Infect Dis. 1949 Mar–Apr;84(2):153–168. [Abstract] [Google Scholar]
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Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

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