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Sindbis virus nsP1 functions in negative-strand RNA synthesis.

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  • 1. Department of Microbiology, Medical College of Ohio, Toledo 43699-0008.
      Authors
    • Wang YF 1
    (1 author)

Journal of Virology, 01 Feb 1991, 65(2):985-988
https://doi.org/10.1128/jvi.65.2.985-988.1991 PMID: 1824787 PMCID: PMC239844

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Abstract 

A mutation at nucleotide 1101 of Sindbis virus ts11 nsP1 caused temperature-sensitive negative-strand synthesis and suppressed the 24R phenotype, which is caused by a mutation in nsP4. Nonstructural proteins synthesized and accumulated by ts11 at 40 degrees C did not cause the reactivation of negative-strand synthesis upon return to 30 degrees C and did not prevent the formation of new replication complexes at 30 degrees C.

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Logo of jvirolLink to Publisher's site
J Virol. 1991 Feb; 65(2): 985–988.
PMCID: PMC239844
PMID: 1824787

Sindbis virus nsP1 functions in negative-strand RNA synthesis.

Y F Wang, S G Sawicki, and D L Sawicki
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Abstract

A mutation at nucleotide 1101 of Sindbis virus ts11 nsP1 caused temperature-sensitive negative-strand synthesis and suppressed the 24R phenotype, which is caused by a mutation in nsP4. Nonstructural proteins synthesized and accumulated by ts11 at 40 degrees C did not cause the reactivation of negative-strand synthesis upon return to 30 degrees C and did not prevent the formation of new replication complexes at 30 degrees C.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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NIAID NIH HHS (1)