Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays

doi:10.1371/journal.pgen.1000167

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PLoS Genet. 2008 Aug; 4(8): e1000167.

Published online 2008 Aug 29. doi: 10.1371/journal.pgen.1000167

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Table 1

Mixtures are composed partially of HapMap individuals empirically evaluated on the Illumina 550 K v3, Illumina 450S Duo, and Affymetrix 5.0 microarrays.

Name	Description	Illumina		Affymetrix
		550 K	450S	5.0
Mixture A	Equimolar pool. Equimolar mixture of 41 CEU individuals (14 Trios minus one individual)	Yes	No	Yes
Mixture B	Equimolar pool. Equimolar mixture of 47 CEU individuals (16 Trios minus one individual)	Yes	No	Yes
Mixture C	2-person mixture. 90% one CEU individual, 10% a second CEU individual	Yes	No	Yes
Mixture D	2-person mixture. 99% one CEU individual, 1% a second CEU individual	Yes	No	Yes
Mixture E	Complex mixture. Mixture with 184 individuals at ~0.2% each, and 41 individuals from Mixture A at ~1% each.	Yes	No	No
Mixture F	Complex mixture. Mixture with 184 individuals at ~0.2% each, and 47 individuals from Mixture B at ~1% each.	Yes	No	Yes
Mixture G	Complex mixture. Mixture with 184 individuals at ~0.2% each, and 41 individuals from Mixture B at ~0.1% each.	No	Yes	No
Mixture H	Complex mixture. Mixture with 184 individuals at ~0.5% each, and 47 individuals from Mixture B at ~0.1% each.	No	Yes	No