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Addition of monoclonal antibodies specific for Rickettsia akari to the rickettsial diagnostic panel.

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  • 1. Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
      Authors
    • McDade JE 1
    (1 author)

Journal of Clinical Microbiology, 01 Oct 1988, 26(10):2221-2223
https://doi.org/10.1128/jcm.26.10.2221-2223.1988 PMID: 3183012 PMCID: PMC266855

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Abstract 

Monoclonal antibodies were produced from mice infected with Rickettsia akari (the etiologic agent of rickettsialpox) and evaluated for specificity in indirect fluorescent-antibody tests with 23 different rickettsial antigens. Of the nine antibodies that were evaluated, two were specific for R. akari and four reacted with R. akari and all other spotted fever group rickettsiae. The remaining three antibodies reacted with some, but not all, members of the spotted fever group. None of the antibodies reacted with typhus, scrub typhus, trench fever, or Q fever rickettsiae. Adding these antibodies to the list of available diagnostic reagents will facilitate identification of rickettsial diseases, particularly those caused by members of the spotted fever group, where the clinical presentations are similar and the etiologic agents are closely related antigenically.

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J Clin Microbiol. 1988 Oct; 26(10): 2221–2223.
PMCID: PMC266855
PMID: 3183012

Addition of monoclonal antibodies specific for Rickettsia akari to the rickettsial diagnostic panel.

J E McDade, C M Black, L F Roumillat, M A Redus, and C L Spruill
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Abstract

Monoclonal antibodies were produced from mice infected with Rickettsia akari (the etiologic agent of rickettsialpox) and evaluated for specificity in indirect fluorescent-antibody tests with 23 different rickettsial antigens. Of the nine antibodies that were evaluated, two were specific for R. akari and four reacted with R. akari and all other spotted fever group rickettsiae. The remaining three antibodies reacted with some, but not all, members of the spotted fever group. None of the antibodies reacted with typhus, scrub typhus, trench fever, or Q fever rickettsiae. Adding these antibodies to the list of available diagnostic reagents will facilitate identification of rickettsial diseases, particularly those caused by members of the spotted fever group, where the clinical presentations are similar and the etiologic agents are closely related antigenically.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Anacker RL, Mann RE, Gonzales C. Reactivity of monoclonal antibodies to Rickettsia rickettsii with spotted fever and typhus group rickettsiae. J Clin Microbiol. 1987 Jan;25(1):167–171. [Europe PMC free article] [Abstract] [Google Scholar]
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